Geometry Adaptation of Protrusion and Polarity Dynamics in Confined Cell Migration
نویسندگان
چکیده
Cell migration in confining physiological environments relies on the concerted dynamics of several cellular components, including protrusions, adhesions with environment, and cell nucleus. However, it remains poorly understood how dynamic interplay these components polarity determine emergent behavior at scale. Here, we combine data-driven inference a mechanistic bottom-up approach to develop model for protrusion confined migration, revealing adapt geometries. Specifically, use experimental data joint protrusion-nucleus trajectories cells micropatterns systematically linking stochastic polarity, This indicates that constrictions through switch from negative positive self-reinforcing feedback loop. Our further reveals this loop leads stereotypical cycles drive constrictions. These are disrupted upon perturbation cytoskeletal indicating is controlled by mechanisms. theoretical therefore identifies adaptation as key mechanism migration.15 MoreReceived 18 May 2022Accepted 23 August 2022DOI:https://doi.org/10.1103/PhysRevX.12.031041Published American Physical Society under terms Creative Commons Attribution 4.0 International license. Further distribution work must maintain attribution author(s) published article’s title, journal citation, DOI.Published SocietyPhysics Subject Headings (PhySH)Research AreasCell adhesionCell locomotionCell migrationCell polarityTechniquesStochastic analysisStochastic differential equationsBiological Physics
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ژورنال
عنوان ژورنال: Physical Review X
سال: 2022
ISSN: ['2160-3308']
DOI: https://doi.org/10.1103/physrevx.12.031041